SCHEMBL9748797

SCHEMBL9748797

CCc1c(C(=O)O)[nH]c(I)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.41
CYP2C9 P11712 3/20 0.41
CYP2C19 P33261 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
PRNP P04156 1/20 0.41
PPARG P37231 1/20 0.41
HIF1A Q16665 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
NR2E3 Q9Y5X4 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
LMNA P02545 1/20 0.40
RAB9A P51151 2/20 0.38
POLB P06746 1/20 0.38
ATM Q13315 1/20 0.38
CYP2D6 P10635 1/20 0.38
FBP1 P09467 4/20 0.37
GPR17 Q13304 6/20 0.36
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
STAT1 P42224 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9423229 0.80 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19NPSR1LMNA
SCHEMBL27562539 0.80 CYP1A2 (0.35) CYP1A2CYP2C9LMNAPOLBCYP2D6
SCHEMBL3281983 0.80 RAB9A (0.54) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL2761841 0.77 CYP1A2 (0.49) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL3285075 0.74 NPSR1 (0.44) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL891106 0.72 NPSR1 (0.54) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL10232133 0.72 LMNA (0.43) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL806470 0.69 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL1919419 0.69 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19NPSR1PRNP
SCHEMBL9424671 0.69 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19NPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515395-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-12-02 EP disclosed
WO-1991009861-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-07-11 WO disclosed