Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748511 | 0.85 | ALDH1A1 (0.58) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| Difloxacin SCHEMBL148765 | 0.84 | LMNA (1.00) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| Difloxacin SCHEMBL29695838 | 0.84 | LMNA (1.00) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL9184515 | 0.84 | KDM4E (0.71) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9748540 | 0.84 | KDM4E (0.71) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10663315 | 0.84 | LMNA (0.68) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| Difloxacin SCHEMBL203110 | 0.83 | LMNA (0.98) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL10561159 | 0.83 | KDM4E (0.70) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10530683 | 0.83 | LMNA (0.69) | LMNAKMT2AMEN1ALDH1A1KDM4E | |
| Difloxacin SCHEMBL27973383 | 0.82 | LMNA (0.96) | LMNAKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-5045549-A | Bactericides | CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) | 1991-09-03 | — | — | US | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |