SCHEMBL9749327

SCHEMBL9749327

CC1(C)CCOc2ccc(O)cc21

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RARA P10276 4/20 0.51
RARB P10826 4/20 0.51
RARG P13631 4/20 0.51
RXRA P19793 2/20 0.45
CYP26A1 O43174 1/20 0.45
CYP26B1 Q9NR63 1/20 0.45
GAA P10253 1/20 0.42
OPRM1 P35372 3/20 0.41
OPRK1 P41145 1/20 0.41
CYP3A4 P08684 1/20 0.41
HNF4A P41235 1/20 0.40
MAP3K14 Q99558 1/20 0.39
MAPT P10636 1/20 0.38
AKR1B1 P15121 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4641520 0.86 MAP3K14 (0.42) RARARARBRARGRXRACYP26A1
SCHEMBL27259563 0.82 RARA (0.51) RARARARBRARGRXRACYP26A1
SCHEMBL8982307 0.81 NOTUM (0.49) RARARARBRARGRXRAGAA
SCHEMBL18211725 0.80 MAP3K14 (0.50) RARARARBRARGRXRACYP26A1
SCHEMBL30353228 0.80 CYP3A4 (0.42) GAAOPRM1OPRK1CYP3A4MAP3K14
SCHEMBL8293244 0.80 RARA (0.49) RARARARBRARGRXRACYP26A1
SCHEMBL9053722 0.79 RARA (0.48) RARARARBRARGRXRACYP26A1
SCHEMBL2599701 0.79 RARA (0.48) RARARARBRARGRXRACYP26A1
SCHEMBL29616597 0.79 RARA (0.48) RARARARBRARGRXRACYP26A1
SCHEMBL12188672 0.79 AKR1B1 (0.57) RARARARBRARGRXRACYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3386506-B1 MODULATORS OF KV3 CHANNELS TO TREAT PAIN AUTIFONY THERAPEUTICS LTD (GB) 2024-01-24 EP disclosed
EP-3390394-B1 HYDANTOIN MODULATORS OF KV3 CHANNELS AUTIFONY THERAPEUTICS LTD (GB) 2022-05-25 EP disclosed
US-20220071998-A1 MODULATORS OF KV3 CHANNELS TO TREAT PAIN AUTIFONY THERAPEUTICS LIMITED (GB) 2022-03-10 US disclosed
US-11180461-B2 Triazoles as Kv3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2021-11-23 US disclosed
US-11147813-B2 Modulators of KV3 channels to treat pain AUTIFONY THERAPEUTICS LIMITED (GB) 2021-10-19 US disclosed
EP-2852589-B1 TRIAZOLES AS KV3 INHIBITORS AUTIFONY THERAPEUTICS LTD (GB) 2021-04-28 EP disclosed
US-20200377485-A1 HYDANTOIN MODULATORS OF KV3 CHANNELS AUTIFONY THERAPEUTICS LTD (GB) 2020-12-03 US disclosed
US-20200172496-A1 TRIAZOLES AS KV3 INHIBITORS AUTIFONY SRL (IT) 2020-06-04 US disclosed
US-10611735-B2 Triazoles as Kv3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2020-04-07 US disclosed
EP-3394061-B1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME (US) 2020-03-11 EP disclosed
WO-2017103604-A1 HYDANTOIN MODULATORS OF KV3 CHANNELS AUTIFONY THERAPEUTICS LIMITED (GB) 2017-06-22 WO disclosed
WO-2017098254-A1 MODULATORS OF KV3 CHANNELS TO TREAT PAIN AUTIFONY THERAPEUTICS LIMITED (GB) 2017-06-15 WO disclosed
US-20160318882-A1 TRIAZOLES AS KV3 INHIBITORS GLAXOSMITHKLINE S.P.A. (IT) 2016-11-03 US disclosed
US-20160318882-A1 TRIAZOLES AS KV3 INHIBITORS GLAXOSMITHKLINE S.P.A. (IT) 2016-11-03 US disclosed
US-9422252-B2 Triazoles as Kv3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2016-08-23 US disclosed
US-9422252-B2 Triazoles as Kv3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2016-08-23 US disclosed
US-20150111910-A1 TRIAZOLES AS KV3 INHIBITORS AUTIFONY THERAPEUTICS LIMITED (GB) 2015-04-23 US disclosed
US-20150111910-A1 TRIAZOLES AS KV3 INHIBITORS AUTIFONY THERAPEUTICS LIMITED (GB) 2015-04-23 US disclosed
EP-0230475-B1 NOVEL UREA DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF AND HERBICIDE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1992-03-18 EP disclosed
US-4838924-A NONPHYTOTOXIC MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10611735-B2 Triazoles as Kv3 inhibitors KCNA3, KCNN3, KCNK3 RARA 4557/4885RARB 4450/4885RARG 4489/4885
US-20150111910-A1 TRIAZOLES AS KV3 INHIBITORS KCNA3, KCNN3, KCNK3 RARA 4557/4885RARB 4450/4885RARG 4489/4885
US-11147813-B2 Modulators of KV3 channels to treat pain KCNN3, KCNA3, KCND3 RARA 4369/4885RARB 4204/4885RARG 4225/4885
US-20200172496-A1 TRIAZOLES AS KV3 INHIBITORS KCNA3, KCNN3, KCNK3 RARA 4557/4885RARB 4450/4885RARG 4489/4885
US-20200377485-A1 HYDANTOIN MODULATORS OF KV3 CHANNELS KCNA3, KCNN3, KCND3 RARA 4576/4885RARB 4489/4885RARG 4422/4885
US-11180461-B2 Triazoles as Kv3 inhibitors KCNA3, KCNN3, KCNK3 RARA 4557/4885RARB 4450/4885RARG 4489/4885
US-20220071998-A1 MODULATORS OF KV3 CHANNELS TO TREAT PAIN KCNN3, KCNA3, KCND3 RARA 4372/4885RARB 4194/4885RARG 4223/4885
US-20160318882-A1 TRIAZOLES AS KV3 INHIBITORS KCNA3, KCNN3, KCNK3 RARA 4557/4885RARB 4450/4885RARG 4489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.