Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | TOP2A | P11388 | 6/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749871 | 0.89 | TOP2A (0.55) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL10425104 | 0.89 | TOP2A (0.55) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL9749358 | 0.88 | KCNH2 (0.45) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL10425073 | 0.86 | KDM4E (0.70) | KCNH2ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL9749343 | 0.86 | KDM4E (0.61) | ALDH1A1POLBKDM4EHPGDHSD17B10 | |
| SCHEMBL12819447 | 0.85 | TOP2A (0.52) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL9749838 | 0.85 | TOP2A (0.53) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL9749882 | 0.85 | KDM4E (0.51) | KCNH2TOP2AALDH1A1POLBOPRM1 | |
| SCHEMBL12818935 | 0.84 | KCNH2 (0.49) | KCNH2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL7821381 | 0.83 | KDM4E (0.69) | KCNH2TOP2ATOP2BALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | claimed |
| US-4806541-A | ANTIBACTERIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | claimed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | claimed |
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| US-4977265-A | WITH BACTERICIDAL ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4946847-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4806541-A | ANTIBACTERIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |