Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10425104 | 1.00 | TOP2A (0.55) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL8112091 | 0.91 | KCNH2 (0.58) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9749353 | 0.89 | KCNH2 (0.55) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9749875 | 0.88 | KCNH2 (0.42) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL12819447 | 0.87 | TOP2A (0.52) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9749838 | 0.87 | TOP2A (0.53) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10425078 | 0.85 | KDM4E (0.64) | KCNH2ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL10425075 | 0.85 | KDM4E (0.64) | KCNH2ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL9749859 | 0.85 | KDM4E (0.45) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10424662 | 0.85 | KDM4E (0.45) | TOP2ATOP2BKCNH2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| US-4977265-A | WITH BACTERICIDAL ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4946847-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4806541-A | ANTIBACTERIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |