Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 2/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749429 | 0.92 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9670575 | 0.86 | KCNH2 (0.60) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL9046371 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10753883 | 0.84 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10753879 | 0.84 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9749468 | 0.84 | KCNH2 (0.51) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10689802 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10621357 | 0.83 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL48145 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL29377022 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |