Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749760 | 1.00 | LMNA (0.53) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9748366 | 0.91 | LMNA (0.66) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9749223 | 0.91 | LMNA (0.66) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL10370052 | 0.89 | LMNA (0.41) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9784901 | 0.88 | EPHA2 (0.47) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9466728 | 0.86 | LMNA (0.44) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9784895 | 0.85 | TOP1 (0.46) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9460824 | 0.84 | LMNA (0.49) | LMNAKMT2AMEN1EPHA2FLT4 | |
| Water SCHEMBL9784852 | 0.83 | LMNA (0.49) | LMNAKMT2AMEN1EPHA2FLT4 | |
| SCHEMBL9784885 | 0.83 | LMNA (0.43) | LMNAKMT2AMEN1EPHA2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |