Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748366 | 1.00 | LMNA (0.66) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9749760 | 0.91 | LMNA (0.53) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9749753 | 0.91 | LMNA (0.53) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10692192 | 0.89 | LMNA (0.52) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| Difloxacin SCHEMBL8206563 | 0.88 | LMNA (0.71) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9784874 | 0.88 | LMNA (0.58) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9784836 | 0.88 | LMNA (0.57) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9784899 | 0.85 | LMNA (0.54) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9129939 | 0.84 | KDM4E (0.61) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9748406 | 0.84 | KDM4E (0.61) | LMNAKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-5045549-A | Bactericides | CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) | 1991-09-03 | — | — | US | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0251308-A1 | 4-Quinolone-3-carboxylic-acid derivatives, process for their synthesis and pharmaceutical preparations containing them | Chemie Linz Gesellschaft m.b.H. (AT) | 1988-01-07 | — | — | EP | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |