Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9552675 | 0.88 | AGTR1 (0.53) | AGTR1AGTR2CNR2LTB4R2BRS3 | |
| SCHEMBL9739523 | 0.85 | FOLH1 (0.43) | FOLH1AGTR1AGTR2CNR2LTB4R | |
| SCHEMBL9552285 | 0.82 | FOLH1 (0.47) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL9528876 | 0.82 | AGTR1 (0.46) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL9552109 | 0.81 | FOLH1 (0.39) | FOLH1AGTR1AGTR2CNR2LTB4R | |
| SCHEMBL9553503 | 0.78 | AGTR1 (0.52) | AGTR1AGTR2LTB4R2BRS3 | |
| SCHEMBL9552744 | 0.78 | AGTR1 (0.53) | AGTR1AGTR2CNR2LTB4R2BRS3 | |
| SCHEMBL9553005 | 0.77 | AGTR1 (0.54) | AGTR1AGTR2CNR2LTB4R2BRS3 | |
| SCHEMBL9553144 | 0.76 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL9553316 | 0.76 | FOLH1 (0.49) | FOLH1AGTR1AGTR2LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |