Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750257 | 0.90 | GRIA2 (0.42) | GRIA2SMN1; SMN2POLBMAPTMPI | |
| SCHEMBL3819871 | 0.90 | MAPT (0.43) | POLBMAPTKDM4EMPITDP1 | |
| SCHEMBL8942200 | 0.87 | GRIA2 (0.42) | GRIA2BACE1MPITDP1 | |
| SCHEMBL9750440 | 0.82 | GRIA2 (0.42) | GRIA2SMN1; SMN2POLBMAPTKDM4E | |
| SCHEMBL9750442 | 0.81 | TDP1 (0.37) | SMN1; SMN2POLBMAPTBACE1MPI | |
| Questiomycin B SCHEMBL9330595 | 0.79 | ALDH1A1 (0.41) | SMN1; SMN2POLBMAPTBACE1KDM4E | |
| SCHEMBL4602650 | 0.78 | TDP1 (0.41) | MAPTKDM4EMPITDP1 | |
| SCHEMBL5851872 | 0.75 | MEN1 (0.37) | SMN1; SMN2POLBMAPTBACE1KDM4E | |
| SCHEMBL5850476 | 0.75 | CYP1A1 (0.48) | MAPTBACE1TDP1 | |
| SCHEMBL22245096 | 0.75 | SMN1; SMN2 (0.56) | GRIA2SMN1; SMN2POLBMTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120858-A | Condensation of 2-methyleneindoline and formic acid in acetic anhydride | MILES INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0058863-B1 | PROCESS FOR THE PREPARATION OF TRIMETHINE DYESTUFFS | BAYER AG (DE) | 1985-01-23 | — | — | EP | disclosed |
| US-4419511-A | Process for the preparation of trimethine dyestuffs | BAYER AKTIENGESELLSCHAFT (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0058863-A1 | Process for the preparation of trimethine dyestuffs | BAYER AG (DE) | 1982-09-01 | — | — | EP | disclosed |