Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL62271 | 0.90 | DNMT1 (0.42) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL3903553 | 0.90 | DNMT1 (0.42) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL6225692 | 0.89 | TP53 (0.38) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL10680234 | 0.89 | DNMT1 (0.41) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL2146169 | 0.88 | TP53 (0.37) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL21805756 | 0.87 | MAPT (0.39) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL21625776 | 0.87 | MAPT (0.41) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL9678206 | 0.85 | DNMT1 (0.39) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL11350903 | 0.85 | HTT (0.42) | TP53MAPTSTAT3HTTSMN1; SMN2 | |
| Triaziquone SCHEMBL20994184 | 0.85 | TP53 (0.36) | TP53MAPTSTAT3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028355-A | Conductive polyurethane foam containing picric acid and analog thereof | CREST-FOAM CORPORATION (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0316446-A4 | IMPROVED CONDUCTIVE POLYURETHANE FOAM COMPOSITIONS AND METHOD | — | 1991-03-20 | — | — | EP | disclosed |
| US-4886626-A | REDUCTION OF ELECTRICAL RESISTANCE | CREST-FOAM CORPORATION (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0316446-A1 | IMPROVED CONDUCTIVE POLYURETHANE FOAM COMPOSITIONS AND METHOD | CREST-FOAM Corp. (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1988009350-A1 | IMPROVED CONDUCTIVE POLYURETHANE FOAM COMPOSITIONS AND METHOD | CREST-FOAM COPORATION (US) | 1988-12-01 | — | — | WO | disclosed |