Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751241 | 0.77 | ALDH1A1 (0.43) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL461696 | 0.64 | ALDH1A1 (0.42) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL9712225 | 0.63 | POLB (0.44) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL6285030 | 0.63 | ALDH1A1 (0.42) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL4277363 | 0.63 | NPC1 (0.45) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL4558468 | 0.62 | KDM1A (0.48) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL11689734 | 0.62 | MAPT (0.46) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL434835 | 0.61 | — | — | |
| SCHEMBL21580197 | 0.61 | NPC1 (0.37) | ALDH1A1NPC1POLBMAPTKMT2A | |
| SCHEMBL28687188 | 0.61 | NPC1 (0.37) | ALDH1A1NPC1POLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386219-A4 | METHOD OF TREATING INFLAMMATION IN MAMMALS UTILIZING KETOBUTYROLACTONES AND FURYLBUTYROLACTONES | — | 1991-11-13 | — | — | EP | disclosed |
| EP-0386219-A1 | METHOD OF TREATING INFLAMMATION IN MAMMALS UTILIZING KETOBUTYROLACTONES AND FURYLBUTYROLACTONES | THERACEL CORPORATION (US) | 1990-09-12 | — | — | EP | disclosed |
| WO-1990001930-A1 | METHOD OF TREATING INFLAMMATION IN MAMMALS UTILIZING KETOBUTYROLACTONES AND FURYLBUTYROLACTONES | THERACEL CORPORATION (US) | 1990-03-08 | — | — | WO | disclosed |
| US-4883813-A | Method of treating inflammation in mammals utilizing ketobutyrolactones and furylbutyrolactones | AMERICAN BIOTECHNOLOGY COMPANY (US) | 1989-11-28 | — | — | US | disclosed |