Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752566 | 0.86 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL9870693 | 0.85 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL9871473 | 0.83 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL9752995 | 0.81 | PDE4B (0.60) | PDE4BPDE4D | |
| SCHEMBL9752495 | 0.81 | PDE4B (0.52) | PDE4BPDE4DKDM4EALDH1A1MEN1 | |
| SCHEMBL9872416 | 0.81 | PDE4B (0.59) | PDE4BPDE4DLMNAKDM4EALDH1A1 | |
| SCHEMBL9870667 | 0.79 | PDE4B (0.45) | PDE4BPDE4DLMNACYP3A4 | |
| SCHEMBL9871070 | 0.79 | PDE4B (0.57) | PDE4BPDE4D | |
| SCHEMBL9870196 | 0.78 | PDE4B (0.56) | PDE4BPDE4DLMNAKDM4EALDH1A1 | |
| SCHEMBL9752783 | 0.78 | PDE4B (0.49) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010664-A1 | PYRIDAZINO[4,5-b]INDOLIZINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-07-25 | — | — | WO | disclosed |
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |