Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870120 | 0.83 | PDE4B (0.41) | PDE4BPDE4D | |
| SCHEMBL9752566 | 0.82 | PDE4B (0.58) | PDE4BPDE4DACHE | |
| SCHEMBL9752585 | 0.82 | PDE4B (0.41) | PDE4BPDE4DNPC1RAB9A | |
| SCHEMBL9870693 | 0.81 | PDE4B (0.58) | PDE4BPDE4DACHE | |
| SCHEMBL9871473 | 0.81 | PDE4B (0.55) | PDE4BPDE4DACHE | |
| SCHEMBL9870727 | 0.80 | LMNA (0.53) | PDE4BPDE4DACHELMNACYP1A2 | |
| SCHEMBL9752708 | 0.80 | PDE4B (0.44) | PDE4BPDE4DNPC1RAB9A | |
| SCHEMBL9871382 | 0.80 | PDE4B (0.44) | PDE4BPDE4DNPC1RAB9A | |
| SCHEMBL9752592 | 0.79 | PDE4B (0.47) | PDE4BPDE4DLMNACYP3A4 | |
| SCHEMBL9752995 | 0.79 | PDE4B (0.60) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |