Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872416 | 0.97 | PDE4B (0.59) | PDE4BPDE4DLMNACYP3A4CYP1A2 | |
| SCHEMBL9870727 | 0.93 | LMNA (0.53) | PDE4BPDE4DLMNACYP3A4CYP1A2 | |
| SCHEMBL9871473 | 0.92 | PDE4B (0.55) | PDE4BPDE4DACHE | |
| SCHEMBL9871070 | 0.91 | PDE4B (0.57) | PDE4BPDE4D | |
| SCHEMBL9752566 | 0.89 | PDE4B (0.58) | PDE4BPDE4DACHE | |
| SCHEMBL9870693 | 0.88 | PDE4B (0.58) | PDE4BPDE4DACHE | |
| SCHEMBL9752995 | 0.88 | PDE4B (0.60) | PDE4BPDE4D | |
| SCHEMBL9752783 | 0.86 | PDE4B (0.49) | PDE4BPDE4D | |
| SCHEMBL8578917 | 0.83 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL9752495 | 0.83 | PDE4B (0.52) | PDE4BPDE4DALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | claimed |
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |