Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | FABP6 | P51161 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2608967 | 0.81 | MAPT (0.46) | MAPTLMNASMN1; SMN2FABP6ALDH1A1 | |
| SCHEMBL7474420 | 0.74 | MAPT (0.47) | MAPTLMNASMN1; SMN2FABP6ALDH1A1 | |
| SCHEMBL15360158 | 0.74 | MAPT (0.50) | MAPTLMNASMN1; SMN2FABP6ALDH1A1 | |
| SCHEMBL7478784 | 0.73 | MAPT (0.62) | MAPTLMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL10460692 | 0.71 | MAPT (0.47) | MAPTLMNASMN1; SMN2GAANPSR1 | |
| SCHEMBL1197644 | 0.70 | KMO (0.50) | MAPTLMNASMN1; SMN2FABP6ALDH1A1 | |
| SCHEMBL8784736 | 0.70 | MAPT (0.51) | MAPTLMNASMN1; SMN2GAARAB9A | |
| SCHEMBL17221445 | 0.70 | MAPT (0.51) | MAPTLMNASMN1; SMN2GAAFABP6 | |
| SCHEMBL12530682 | 0.69 | LMNA (0.48) | MAPTLMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL9752577 | 0.68 | POLB (0.46) | RAD52NPSR1PRMT5POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | claimed |
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | disclosed |