Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.76 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.76 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.76 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.76 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.76 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.76 |
| ▸ | GABRP | O00591 | 9/20 | 0.76 |
| ▸ | GABRD | O14764 | 9/20 | 0.76 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.76 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.76 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.76 |
| ▸ | GABRE | P78334 | 9/20 | 0.76 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.76 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.76 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.76 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584297 | 0.94 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845300 | 0.91 | GABRA1 (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9082037 | 0.87 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623807 | 0.87 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623763 | 0.87 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845201 | 0.86 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8473459 | 0.85 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8845445 | 0.85 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31623770 | 0.85 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9583395 | 0.84 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460153-A1 | NEW-$g(b)-CARBOLINS, PROCESS FOR PREPARING THEM AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-12-11 | — | — | EP | disclosed |
| WO-1991009858-A1 | NEW-β-CARBOLINS, PROCESS FOR PREPARING THEM AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-07-11 | — | — | WO | disclosed |