Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752928 | 0.88 | MAPK14 (0.43) | MAPK14PTGS2KDM5BCSNK1DCSNK1A1 | |
| SCHEMBL9753682 | 0.83 | MAPK14 (0.40) | MAPK14PTGS2KDM5BCSNK1DCSNK1A1 | |
| SCHEMBL9753686 | 0.83 | MAPK14 (0.40) | MAPK14PTGS2KDM5BCSNK1DCSNK1A1 | |
| SCHEMBL9753309 | 0.78 | MAPK14 (0.43) | MAPK14PTGS2KDM5BGCGR | |
| SCHEMBL9753416 | 0.75 | POLB (0.37) | MAPK14PTGS2KDM5BPTGS1 | |
| SCHEMBL9752986 | 0.75 | MAPK14 (0.38) | MAPK14PTGS2GCGRNPC1RAB9A | |
| SCHEMBL9753114 | 0.74 | MAPK14 (0.42) | MAPK14PTGS2KDM5BPTGS1 | |
| SCHEMBL9753119 | 0.74 | PTGS2 (0.36) | PTGS2KDM5BPTGS1HTR2AHTR2C | |
| SCHEMBL9753359 | 0.74 | HMGCR (0.54) | PTGS2 | |
| SCHEMBL9753314 | 0.72 | KDM5B (0.34) | MAPK14PTGS2KDM5BPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |