Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753037 | 1.00 | AKT1 (0.36) | AKT1AKT2PTGS2POLBSTAT1 | |
| SCHEMBL9752959 | 0.90 | POLB (0.38) | AKT1AKT2PTGS2POLBSTAT1 | |
| SCHEMBL9753676 | 0.88 | PTGS2 (0.37) | PTGS2KMT2ANPC1 | |
| SCHEMBL9753671 | 0.88 | PTGS2 (0.37) | PTGS2KMT2ANPC1 | |
| SCHEMBL9753411 | 0.80 | HMGCR (0.53) | HMGCR | |
| SCHEMBL9753319 | 0.80 | HMGCR (0.43) | HMGCR | |
| SCHEMBL9753326 | 0.80 | HMGCR (0.43) | HMGCR | |
| SCHEMBL9753490 | 0.80 | POLB (0.34) | PTGS2POLBHMGCRKMT2AATM | |
| SCHEMBL9753491 | 0.80 | POLB (0.34) | PTGS2POLBHMGCRKMT2AATM | |
| SCHEMBL9753682 | 0.79 | MAPK14 (0.40) | PTGS2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |