Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL27340939 | 0.96 | — | — | |
| Histamine SCHEMBL289072 | 0.96 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL2279 | 0.96 | — | — | |
| Histamine SCHEMBL1668636 | 0.96 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL5447892 | 0.96 | — | — | |
| Histamine SCHEMBL7444650 | 0.96 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL28875895 | 0.94 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL991718 | 0.93 | — | — | |
| Histamine SCHEMBL931130 | 0.93 | — | — | |
| Histamine SCHEMBL21806473 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010427-A2 | THE EFFECT OF TRANSGLUTAMINASE INHIBITION ON MICROFILARIAE DEVELOPMENT AND MACROFILARIAE VIABILITY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-07-25 | — | — | WO | claimed |