Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753232 | 0.89 | MAPK14 (0.33) | MAPK14PTGS2KMT2AKDM5B | |
| SCHEMBL9753231 | 0.89 | MAPK14 (0.33) | MAPK14PTGS2KMT2AKDM5B | |
| SCHEMBL27529264 | 0.80 | PPP1CA (0.37) | ALDH1A1MAPK14PTGS2KMT2AKDM5B | |
| SCHEMBL9753334 | 0.79 | GCGR (0.38) | MAPK14 | |
| SCHEMBL9753321 | 0.78 | MAPK14 (0.44) | ALDH1A1MAPK14PTGS2KMT2AKDM5B | |
| SCHEMBL9752987 | 0.78 | HMGCR (0.40) | ALDH1A1 | |
| SCHEMBL9752988 | 0.78 | HMGCR (0.40) | ALDH1A1 | |
| SCHEMBL9753324 | 0.77 | HMGCR (0.51) | ALDH1A1PTGS2 | |
| SCHEMBL9753668 | 0.75 | GRM6 (0.41) | ALDH1A1PTGS2KMT2ALMNATP53 | |
| SCHEMBL9753114 | 0.75 | MAPK14 (0.42) | ALDH1A1MAPK14PTGS2KMT2AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |