Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378650 | 0.87 | TGFBR1 (0.36) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL21816320 | 0.84 | TGFBR1 (0.39) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL29882522 | 0.84 | TGFBR1 (0.41) | TGFBR1RAB9ANPC1KDM4ETGFBR2 | |
| SCHEMBL8609510 | 0.83 | HDAC4 (0.34) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| Lithium SCHEMBL31337115 | 0.82 | TGFBR1 (0.40) | TGFBR1RAB9ANPC1KDM4ETGFBR2 | |
| Lithium Ion SCHEMBL31133356 | 0.82 | TGFBR1 (0.40) | TGFBR1RAB9ANPC1KDM4ETGFBR2 | |
| SCHEMBL8609509 | 0.81 | TGFBR1 (0.34) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL12549863 | 0.80 | HDAC4 (0.34) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL8607229 | 0.80 | LMNA (0.35) | HDAC4HDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL8605173 | 0.80 | P4HTM (0.36) | TGFBR1RAB9ANPC1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |