Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924842 | 1.00 | MME (0.44) | MMEALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8733280 | 0.89 | MME (0.48) | MMEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8894558 | 0.89 | MME (0.48) | MMEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL6430188 | 0.89 | MME (0.52) | MMEALDH1A1 | |
| SCHEMBL9337016 | 0.89 | MME (0.52) | MMEALDH1A1 | |
| SCHEMBL9753833 | 0.86 | MME (0.49) | MMEALDH1A1CTSLCTSBCTSS | |
| SCHEMBL5925056 | 0.86 | MME (0.49) | MMEALDH1A1CTSLCTSBCTSS | |
| SCHEMBL5796118 | 0.85 | MME (0.48) | MMEALDH1A1CTSLCTSBCTSS | |
| SCHEMBL7321839 | 0.84 | MME (0.45) | MMECTSS | |
| SCHEMBL7441985 | 0.83 | MME (0.52) | MMEALDH1A1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010644-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |