Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733280 | 1.00 | MME (0.48) | MMESMN1; SMN2ACEALDH1A1L3MBTL1 | |
| SCHEMBL5924842 | 0.89 | MME (0.44) | MMEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9753583 | 0.89 | MME (0.44) | MMEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7321839 | 0.85 | MME (0.45) | MME | |
| SCHEMBL9753945 | 0.83 | MME (0.51) | MME | |
| SCHEMBL7304172 | 0.83 | SMN1; SMN2 (0.43) | MMESMN1; SMN2ACEL3MBTL1MEN1 | |
| SCHEMBL9337016 | 0.82 | MME (0.52) | MMEALDH1A1 | |
| SCHEMBL6430188 | 0.82 | MME (0.52) | MMEALDH1A1 | |
| SCHEMBL4841680 | 0.82 | SLC15A1 (0.45) | MMEALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL9753937 | 0.82 | SMN1; SMN2 (0.44) | MMESMN1; SMN2ACEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677297-A | ENZYME INHIBITOR FOR TREATING THE HEART FAILURE TO REDUCE THE CARDIAC PRESSURE, DIURETICS | SOLVAY PHARMACEUTICALS GMBH (DE) | 1997-10-14 | — | — | US | disclosed |
| WO-1991010644-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |