Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COPS5 | Q92905 | 1/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CDC42 | P60953 | 1/20 | 0.40 |
| ▸ | RAC1 | P63000 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803993 | 0.84 | COPS5 (0.47) | COPS5ALOX5APAKR1C3AKR1C2PTGS1 | |
| SCHEMBL9754184 | 0.81 | COPS5 (0.47) | COPS5ALOX5APAKR1C3AKR1C2PTGS1 | |
| SCHEMBL9803803 | 0.74 | COPS5 (0.46) | COPS5ALOX5APAKR1C3AKR1C2PTGS1 | |
| Ketoprofen SCHEMBL7624389 | 0.73 | PTGS2 (0.59) | AKR1C3AKR1C2PTGS1AKR1C1PTGS2 | |
| SCHEMBL9754159 | 0.70 | COPS5 (0.53) | COPS5AKR1C3AKR1C2PTGS1AKR1C1 | |
| Naproxen SCHEMBL16050244 | 0.70 | AKR1C3 (0.76) | AKR1C3AKR1C2PTGS1AKR1C1PTGS2 | |
| Naproxen SCHEMBL1444674 | 0.70 | AKR1C3 (0.76) | AKR1C3AKR1C2PTGS1AKR1C1PTGS2 | |
| Naproxen SCHEMBL8555553 | 0.70 | AKR1C3 (0.76) | AKR1C3AKR1C2PTGS1AKR1C1PTGS2 | |
| SCHEMBL9754050 | 0.68 | COPS5 (0.53) | COPS5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL9803514 | 0.67 | S1PR1 (0.42) | ALOX5APAKR1C3AKR1C2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |