Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | MTOR | P42345 | 2/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.72 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.72 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11879932 | 0.86 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL11422515 | 0.86 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL13003005 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL26320640 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL20668731 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL9467302 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| Cifostodine SCHEMBL30753567 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| Cifostodine SCHEMBL1229741 | 0.85 | LMNA (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL22678626 | 0.85 | LMNA (0.92) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL9140489 | 0.85 | LMNA (0.74) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019727-A1 | 5'-HYDROGENPHOSPHONATES AND 5'-METHYLPHOSPHONATES OF SUGAR MODIFIED NUCLEOSIDES, COMPOSITIONS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-12-26 | — | — | WO | disclosed |