Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.34 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.34 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.34 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.34 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.34 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844893 | 0.84 | DRD2 (0.50) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL20520367 | 0.76 | PARP10 (0.44) | KDM1A | |
| SCHEMBL19579719 | 0.70 | HTR2C (0.48) | — | |
| SCHEMBL9618452 | 0.69 | — | — | |
| SCHEMBL9529812 | 0.69 | DRD2 (0.47) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL7469508 | 0.68 | CA2 (0.43) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL4030395 | 0.68 | DRD2 (0.79) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL31317940 | 0.68 | DRD2 (0.79) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL222933 | 0.68 | HTR2C (0.37) | KDM1A | |
| SCHEMBL33917 | 0.67 | DRD2 (0.70) | DRD2DRD4DRD1DRD3DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992000072-A1 | TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO[2,3-B]INDOLE | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-09 | — | — | WO | disclosed |