Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.31 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757122 | 0.78 | MEN1 (0.45) | L3MBTL1ELANEHPGDSMN1; SMN2MEN1 | |
| SCHEMBL15961465 | 0.76 | NPC1 (0.50) | ATMNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8117279 | 0.72 | DHODH (0.58) | ATML3MBTL1DHODHELANENPC1 | |
| SCHEMBL21612962 | 0.71 | NPC1 (0.60) | ATML3MBTL1DHODHELANENPC1 | |
| SCHEMBL29506408 | 0.71 | PRKDC (0.38) | HPGDKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL3378970 | 0.71 | PRKDC (0.38) | HPGDKMT2AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3378814 | 0.70 | PRKDC (0.37) | HPGDKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL10477346 | 0.69 | PKM (0.44) | L3MBTL1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL10477438 | 0.69 | KDM4E (0.38) | ATML3MBTL1NPC1RAB9AHPGD | |
| SCHEMBL11146024 | 0.67 | ALDH1A1 (0.38) | L3MBTL1AXLNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |