Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757008 | 0.72 | BRD4 (0.33) | ALDH1A1KDM4EBRD4CREBBPCYP2C9 | |
| SCHEMBL9635634 | 0.71 | KDM4E (0.56) | ALDH1A1KDM4EHSD17B10MAPTKMT2A | |
| SCHEMBL9757013 | 0.64 | GAA (0.39) | ALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL29999108 | 0.59 | BRD4 (0.42) | ALDH1A1KDM4EBRD4CREBBPMEN1 | |
| SCHEMBL3658691 | 0.56 | ADRA2A (0.45) | CYP2C9HSD17B10MEN1KMT2A | |
| SCHEMBL3657905 | 0.56 | ADRA2A (0.45) | CYP2C9HSD17B10MEN1KMT2A | |
| SCHEMBL6379988 | 0.56 | FFAR1 (0.57) | CYP2C9HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL13564512 | 0.56 | FFAR1 (0.57) | CYP2C9HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL11001228 | 0.56 | PTGS1 (0.44) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL6045738 | 0.55 | ALOX5 (0.46) | ALDH1A1KDM4EBRD4CREBBPHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |