Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757043 | 1.00 | CYSLTR1 (0.50) | CYSLTR1CYSLTR2PSMB8PSMB5MAOA | |
| SCHEMBL9756995 | 0.81 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2MAOAMAOBTLR4 | |
| SCHEMBL9756989 | 0.81 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2MAOAMAOBTLR4 | |
| SCHEMBL9757039 | 0.79 | PSMB8 (0.46) | CYSLTR1CYSLTR2PSMB8PSMB5MAOA | |
| SCHEMBL9757085 | 0.75 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757086 | 0.75 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757167 | 0.74 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2MAOAMAOBTLR4 | |
| SCHEMBL9757140 | 0.74 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2MAOAMAOBTLR4 | |
| SCHEMBL9757153 | 0.73 | GPBAR1 (0.52) | CYSLTR1CYSLTR2 | |
| SCHEMBL14843695 | 0.73 | CYSLTR2 (0.59) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |