Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756995 | 1.00 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757140 | 0.94 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757167 | 0.94 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757187 | 0.91 | TEC (0.38) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757288 | 0.91 | CYSLTR2 (0.46) | CYSLTR1CYSLTR2TLR4TLR2 | |
| SCHEMBL9757240 | 0.91 | TEC (0.38) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757170 | 0.87 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757138 | 0.86 | CYSLTR1 (0.40) | CYSLTR1CYSLTR2 | |
| SCHEMBL9756956 | 0.85 | CYSLTR1 (0.42) | CYSLTR1CYSLTR2FFAR1PPARDPPARA | |
| SCHEMBL9757231 | 0.83 | RAB9A (0.40) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |