Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756982 | 0.82 | FFAR1 (0.39) | NR4A2MAOAMAOBFFAR1PPARD | |
| SCHEMBL9757043 | 0.79 | CYSLTR1 (0.50) | PSMB8PSMB5MAOAMAOBCYSLTR2 | |
| SCHEMBL9757046 | 0.79 | CYSLTR1 (0.50) | PSMB8PSMB5MAOAMAOBCYSLTR2 | |
| SCHEMBL9757132 | 0.76 | FFAR1 (0.43) | NR4A2MAOAMAOBFFAR1PPARD | |
| SCHEMBL9757153 | 0.73 | GPBAR1 (0.52) | CYSLTR2CYSLTR1 | |
| SCHEMBL9757283 | 0.72 | CYSLTR1 (0.38) | F2CYSLTR2CYSLTR1 | |
| SCHEMBL9757175 | 0.72 | TEC (0.37) | NR4A2MAOAMAOBFFAR1PPARD | |
| SCHEMBL9757151 | 0.71 | NR4A2 (0.43) | NR4A2MAOAMAOBSMPD1CYSLTR2 | |
| SCHEMBL9757164 | 0.70 | NR4A2 (0.33) | NR4A2MAOAMAOBFFAR1PPARD | |
| SCHEMBL9760316 | 0.69 | CYSLTR1 (0.54) | FFAR1CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |