Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757152 | 0.82 | MAPT (0.60) | NPC1RAB9ALMNAPOLBMAPT | |
| SCHEMBL22629662 | 0.81 | NPC1 (0.52) | NPC1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL5624696 | 0.77 | MAPT (0.54) | NPC1RAB9ALMNAMAPTKDM4E | |
| SCHEMBL11326015 | 0.77 | RPS6KB2 (0.48) | NPC1RAB9AMAPTGAAKDM4E | |
| SCHEMBL11333951 | 0.74 | AGPAT2 (0.47) | NPC1RAB9AMAPTGAAKDM4E | |
| SCHEMBL9756970 | 0.73 | ALOX5 (0.54) | — | |
| SCHEMBL9756971 | 0.73 | ALOX5 (0.45) | — | |
| SCHEMBL11310133 | 0.73 | MEN1 (0.55) | NPC1RAB9ALMNAPOLBMAPT | |
| SCHEMBL21814756 | 0.72 | MEN1 (0.54) | NPC1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL9757118 | 0.71 | CYP4F2 (0.49) | LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |