Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11333951 | 0.89 | AGPAT2 (0.47) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10033451 | 0.86 | MAPT (0.66) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22629662 | 0.84 | NPC1 (0.52) | MAPTKDM4ENPC1RAB9ATP53 | |
| SCHEMBL11191233 | 0.84 | MAPT (0.66) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9757094 | 0.82 | NPC1 (0.45) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL5624696 | 0.81 | MAPT (0.54) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11326015 | 0.80 | RPS6KB2 (0.48) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14045318 | 0.76 | NPC1 (0.60) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24766804 | 0.76 | GAA (0.49) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11310133 | 0.76 | MEN1 (0.55) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |