Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9549209 | 0.93 | HTT (0.44) | HTTDNM1GAAKMT2A | |
| SCHEMBL23001106 | 0.88 | HTT (0.46) | HTTDNM1KMT2A | |
| SCHEMBL10575712 | 0.85 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 | |
| SCHEMBL10528405 | 0.85 | ALDH1A1 (0.40) | HTTDNM1GAAKMT2A | |
| SCHEMBL9548987 | 0.84 | GAA (0.38) | HTTGAAKMT2A | |
| Hydrochloric Acid SCHEMBL9549118 | 0.82 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL9549172 | 0.82 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL9549535 | 0.82 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL9549295 | 0.82 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL9549087 | 0.82 | HTT (0.41) | HTTDNM1GAAPLA2G1BHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287649-A4 | COMPOSITIONS USED IN PERMANENT STRUCTURE ALTERING OF HAIR | — | 1991-08-21 | — | — | EP | disclosed |
| US-4871535-A | PERMANENT WAVES | GAF CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0287649-A1 | COMPOSITIONS USED IN PERMANENT STRUCTURE ALTERING OF HAIR | GAF CHEMICALS CORPORATION (US) | 1988-10-26 | — | — | EP | disclosed |
| WO-1988002997-A1 | COMPOSITIONS USED IN PERMANENT STRUCTURE ALTERING OF HAIR | GAF CORPORATION (US) | 1988-05-05 | — | — | WO | disclosed |