Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757215 | 0.86 | ALOX5AP (0.38) | CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL9757127 | 0.84 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2ALOX5APPPARGPPARD | |
| SCHEMBL9673252 | 0.79 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL9760905 | 0.78 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL9756990 | 0.73 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757016 | 0.72 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757114 | 0.72 | CYSLTR2 (0.46) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757125 | 0.71 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757105 | 0.70 | GPBAR1 (0.45) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757276 | 0.70 | CYSLTR2 (0.49) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |