Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.53 |
| ▸ | TOP2A | P11388 | 11/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757211 | 0.89 | TOP2A (0.49) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9757657 | 0.89 | EPHA2 (0.45) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9757355 | 0.86 | KDM4E (0.44) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9757418 | 0.82 | TOP1 (0.55) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL6220162 | 0.80 | ALDH1A1 (0.64) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL31435135 | 0.80 | ALDH1A1 (0.64) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9870380 | 0.79 | KDM4E (0.64) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9666805 | 0.78 | KDM4E (0.51) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL9871193 | 0.77 | KDM4E (0.64) | TOP1TOP2AEPHA2FLT4GSK3B | |
| SCHEMBL13581395 | 0.77 | TOP1 (0.53) | TOP1TOP2AEPHA2FLT4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026856-A | Bactericides | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-06-25 | — | — | US | disclosed |
| EP-0343560-A2 | Isoindoline derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1989-11-29 | — | — | EP | disclosed |