Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.86 |
| ▸ | DRD3 | P35462 | 11/20 | 0.86 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HTR1D | P28221 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701521 | 0.93 | DRD2 (1.00) | DRD2DRD3POLBKMT2AHTR1D | |
| SCHEMBL2702018 | 0.93 | DRD2 (1.00) | DRD2DRD3POLBKMT2AHTR1D | |
| SCHEMBL8394614 | 0.93 | DRD2 (1.00) | DRD2DRD3POLBKMT2AHTR1D | |
| Hydrochloric Acid SCHEMBL6339640 | 0.91 | DRD2 (0.97) | DRD2DRD3POLBKMT2AHTR1D | |
| SCHEMBL607070 | 0.87 | DRD2 (0.90) | DRD2DRD3POLBKMT2AHTR1D | |
| Hydrochloric Acid SCHEMBL11488842 | 0.86 | DRD2 (0.87) | DRD2DRD3POLBKMT2AHTR1D | |
| SCHEMBL6404849 | 0.82 | POLB (0.76) | DRD2DRD3POLBKMT2AGRIN1 | |
| SCHEMBL6404851 | 0.82 | POLB (0.76) | DRD2DRD3POLBKMT2AGRIN1 | |
| SCHEMBL8689197 | 0.82 | DRD2 (0.79) | DRD2DRD3POLBKMT2AHTR1D | |
| SCHEMBL6334450 | 0.81 | DRD2 (0.78) | DRD2DRD3POLBKMT2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407416-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-16 | — | — | EP | disclosed |
| WO-1989009050-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1989-10-05 | — | — | WO | disclosed |