Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | HTR1D | P28221 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759262 | 0.84 | HTR1A (0.53) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL9759323 | 0.80 | HTR1D (0.59) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL9758858 | 0.79 | HTR1A (0.62) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL2218622 | 0.77 | DRD2 (0.82) | DRD2HTR1DDRD3HTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL9355015 | 0.76 | DRD2 (0.81) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL8902681 | 0.74 | DRD2 (1.00) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL8902966 | 0.74 | DRD2 (1.00) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL8902678 | 0.74 | DRD2 (1.00) | DRD2HTR1DDRD3HTR1AHTR1B | |
| SCHEMBL9759242 | 0.74 | HTR1D (0.71) | DRD2HTR1DDRD3HTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL8904336 | 0.73 | DRD2 (0.98) | DRD2HTR1DDRD3HTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047422-A | Treating A Disorder Of The Central Nervous System, Cardiovascular System Or Intestinal Tract | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-10 | — | — | US | disclosed |
| US-4968679-A | DISORDERS OF CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| US-4873262-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0272534-A2 | 8-substituted 2-aminotetralins | BAYER AG (DE) | 1988-06-29 | — | — | EP | disclosed |