Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.38 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9758667 | 1.00 | LMNA (0.43) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Fumaric Acid SCHEMBL9759360 | 0.92 | BCHE (0.39) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Fumaric Acid SCHEMBL9759336 | 0.92 | BCHE (0.39) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Fumaric Acid SCHEMBL9758792 | 0.89 | KMT2A (0.41) | LMNASMN1; SMN2NPSR1TP53KMT2A | |
| Fumaric Acid SCHEMBL9758783 | 0.89 | KMT2A (0.41) | LMNASMN1; SMN2NPSR1TP53KMT2A | |
| Apadoline SCHEMBL29878314 | 0.86 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Apadoline SCHEMBL635109 | 0.86 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Apadoline SCHEMBL31300302 | 0.86 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Apadoline SCHEMBL7518667 | 0.86 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1BCHETP53 | |
| Fumaric Acid SCHEMBL9758663 | 0.85 | LMNA (0.42) | LMNASMN1; SMN2NPSR1BCHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985419-A | Analgesics, Diuretics | RHONE-POULENC SANTE (FR) | 1991-01-15 | — | — | US | disclosed |