Sugi Predict

Sugi Predict / Compounds / SCHEMBL975873

SCHEMBL975873

SCHEMBL975873

COc1cc(-c2nnc(N)nc2N)cc(OC)c1OC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.50
▸ TSHR P16473 2/20 0.50
▸ POLB P06746 1/20 0.50
▸ DHFR P00374 3/20 0.49
▸ ADORA2A P29274 1/20 0.48
▸ ADORA1 P30542 1/20 0.48
▸ CSNK1A1 P48729 1/20 0.47
▸ CLK4 Q9HAZ1 1/20 0.47
▸ FYN P06241 1/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ HPGD P15428 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ SLC22A1 O15245 1/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ NFKB1 P19838 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ BLM P54132 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29870262 1.00 KDM4E (0.50) KDM4ETSHRPOLBDHFRADORA2A
SCHEMBL976983 0.82 KDM4E (0.51) KDM4EDHFRADORA1CSNK1A1CLK4
SCHEMBL29870480 0.82 KDM4E (0.51) KDM4EDHFRADORA1CSNK1A1CLK4
SCHEMBL29870529 0.79 ADORA2A (0.65) ADORA2AADORA1CSNK1A1CLK4ALDH1A1
SCHEMBL978983 0.79 ADORA2A (0.65) ADORA2AADORA1CSNK1A1CLK4ALDH1A1
SCHEMBL27612599 0.79 ADORA2A (0.53) KDM4ETSHRPOLBDHFRADORA2A
Hydrochloric Acid SCHEMBL6462970 0.76 ADORA2A (0.45) KDM4ETSHRPOLBDHFRADORA2A
SCHEMBL6385078 0.75 KDM4E (0.49) KDM4ETSHRPOLBDHFRADORA2A
SCHEMBL1122200 0.75 FYN (0.53) KDM4ETSHRPOLBDHFRADORA2A
SCHEMBL2323350 0.75 PDGFRB (0.54) TSHRADORA2AADORA1FYNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN claimed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP claimed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US claimed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US claimed
EP-3307273-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS University of Greenwich (GB) 2018-04-18 — — EP claimed
US-9862691-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2018-01-09 — — US claimed
WO-2016198878-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2016-12-15 — — WO claimed
US-20160311784-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2016-10-27 — — US claimed
EP-3002280-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2016-04-06 — — EP claimed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US claimed
EP-3002280-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2023-05-24 — — EP disclosed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP disclosed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US disclosed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US disclosed
EP-3307273-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS University of Greenwich (GB) 2018-04-18 — — EP disclosed
CN-101918378-B Cyclic azide and sodium diazoxide channel blockers UNIV GREENWICH 2013-12-04 — — CN disclosed
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2011-01-13 — — US disclosed
CN-101918378-A Cyclic azide and sodium diazoxide channel blockers UNIV GREENWICH 2010-12-15 — — CN disclosed
EP-2229371-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2010-09-22 — — EP disclosed
WO-2009090431-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2009-07-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A KDM4E 4414/4885TSHR 295/4885POLB 2298/4885
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS CACNA1E, SCN2B, SCN3A KDM4E 2563/4885TSHR 77/4885POLB 2688/4885
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors IFNG, IFNAR1, IRF3 KDM4E 4417/4885TSHR 498/4885POLB 199/4885
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS IFNG, IFNAR1, IRF3 KDM4E 4417/4885TSHR 498/4885POLB 199/4885
US-20160311784-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A KDM4E 4452/4885TSHR 309/4885POLB 2165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.