Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28855953 | 0.78 | FYN (0.53) | FYNPIK3CDABL1EGFRHCK | |
| SCHEMBL29870262 | 0.75 | KDM4E (0.50) | FYNTSHRKDM4EPOLBMEN1 | |
| SCHEMBL975873 | 0.75 | KDM4E (0.50) | FYNTSHRKDM4EPOLBMEN1 | |
| SCHEMBL6722240 | 0.73 | KMT2A (0.55) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL20589749 | 0.72 | FYN (0.50) | FYNTSHRKDM4EPOLBGAA | |
| SCHEMBL28901285 | 0.71 | TUBB4A (0.47) | FYNADORA2AADORA1 | |
| SCHEMBL27612599 | 0.71 | ADORA2A (0.53) | FYNPIK3CDABL1EGFRHCK | |
| SCHEMBL2437579 | 0.71 | DHFR (0.67) | FYNTSHRGAATGFBR1MEN1 | |
| SCHEMBL20589457 | 0.70 | ABL1 (0.64) | FYNABL1TGFBR1CHEK2 | |
| SCHEMBL30268270 | 0.70 | PIK3CD (0.49) | FYNPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831184-B1 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | WELLCOME TRUST LTD (GB) | 2011-02-09 | — | — | EP | disclosed |