Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.46 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16914897 | 0.87 | ALDH1A1 (0.59) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 | |
| SCHEMBL9732623 | 0.85 | CYP11B1 (0.44) | ALDH1A1MAPK1CYP3A4CHRM5CHKA | |
| SCHEMBL9759941 | 0.81 | F2 (0.48) | ALDH1A1CYP3A4TDP1MAPTTSHR | |
| SCHEMBL177904 | 0.81 | MAPT (0.52) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 | |
| SCHEMBL55931 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 | |
| SCHEMBL14409566 | 0.81 | CHRM5 (0.52) | ALOX15CHRM5CHKAMAPTSMN1; SMN2 | |
| SCHEMBL2392177 | 0.81 | CYP3A4 (0.47) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL3570619 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 | |
| SCHEMBL4700413 | 0.79 | CHRM5 (0.50) | CHRM5CHKAMAPTSMN1; SMN2 | |
| SCHEMBL10955815 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPK1CYP3A4TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |