Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412648 | 0.82 | ALDH1A1 (0.47) | TDP1CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9759914 | 0.81 | ALDH1A1 (0.46) | CGASTDP1CYP2D6CYP3A4TSHR | |
| SCHEMBL9760110 | 0.79 | KCNH2 (0.56) | F2CHRNB2CHRNA4ALDH1A1MAPT | |
| SCHEMBL9759926 | 0.76 | KCNH2 (0.58) | F2PRSS2CTRCCYP2D6CYP1A2 | |
| SCHEMBL23634085 | 0.76 | NPC1 (0.46) | TDP1CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3117214 | 0.76 | KMT2A (0.59) | TDP1CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL56571 | 0.76 | KEAP1 (0.67) | TDP1TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL2022333 | 0.76 | KCNH2 (0.56) | TDP1TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL9732623 | 0.76 | CYP11B1 (0.44) | CGASCYP2D6CYP3A4TSHRHRH3 | |
| SCHEMBL23634075 | 0.75 | KDM4E (0.46) | TDP1TSHRKEAP1NFE2L2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |