Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.58 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760114 | 0.85 | NR3C2 (0.51) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9847950 | 0.78 | KCNH2 (0.48) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL7861253 | 0.77 | KCNH2 (0.78) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9759941 | 0.76 | F2 (0.48) | NPC1RAB9AF2PRSS2CTRC | |
| SCHEMBL10425925 | 0.75 | NPC1 (0.66) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL6102734 | 0.74 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9760110 | 0.74 | KCNH2 (0.56) | KCNH2F2POLB | |
| Dofetilide SCHEMBL16135 | 0.74 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL7854083 | 0.74 | KCNH2 (0.72) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL1284402 | 0.73 | F2 (0.47) | F2PRSS2CTRCSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |