Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101724 | 0.81 | KMT2A (0.78) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL28932333 | 0.78 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL10085009 | 0.76 | KDM4E (0.68) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL6982894 | 0.74 | HPGD (1.00) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL30877025 | 0.74 | HPGD (1.00) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL6218489 | 0.74 | HPGD (0.65) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL9760455 | 0.73 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL7098938 | 0.73 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL2611397 | 0.72 | KDM4E (0.59) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 | |
| SCHEMBL17242550 | 0.72 | KDM4E (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |