Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760318 | 0.87 | HSD17B10 (0.48) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL9761079 | 0.86 | L3MBTL1 (0.46) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL4985915 | 0.84 | HSD17B10 (0.50) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL4985724 | 0.83 | L3MBTL1 (0.48) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL4983346 | 0.83 | HSD17B10 (0.53) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL9761313 | 0.80 | SMN1; SMN2 (0.52) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL10766778 | 0.79 | SMN1; SMN2 (0.46) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL7272170 | 0.79 | SMN1; SMN2 (0.46) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL5050634 | 0.79 | NPSR1 (0.61) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 | |
| SCHEMBL10768404 | 0.78 | POLB (0.46) | HSD17B10POLBAPEX1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026863-A | Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4983740-A | Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide | ADIR ET COMPAGNIE (FR) | 1991-01-08 | — | — | US | disclosed |
| US-4870091-A | CALCIUM CHANNEL BLOCKERS | ADIR ET CIE (FR) | 1989-09-26 | — | — | US | disclosed |