Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18660127 | 0.89 | MAPT (0.77) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL1728626 | 0.84 | MAPT (0.70) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL177662 | 0.84 | MAPT (0.53) | MAPTPOLBCRHBPCRHR2NPC1 | |
| SCHEMBL9760110 | 0.84 | KCNH2 (0.56) | MAPTPOLBALDH1A1 | |
| SCHEMBL2393251 | 0.84 | CRHBP (0.68) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL16706324 | 0.81 | MAPT (0.81) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL6372266 | 0.80 | MAPT (0.64) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL27877152 | 0.80 | POLB (0.53) | MAPTPOLBCRHBPCRHR2NPC1 | |
| SCHEMBL1729465 | 0.79 | MAPT (0.68) | MAPTPOLBCRHBPCRHR2MMP14 | |
| SCHEMBL27927482 | 0.79 | MAPT (0.68) | MAPTPOLBCRHBPCRHR2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |