Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PRF1 | P14222 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21619352 | 0.88 | LMNA (0.67) | CD274LMNAPRF1CYP2C19KMT2A | |
| SCHEMBL17652863 | 0.85 | CD274 (0.59) | CD274LMNACYP2C19ALDH1A1HTR1A | |
| SCHEMBL1185112 | 0.84 | LMNA (0.78) | CD274LMNACYP2C19ALDH1A1POLB | |
| SCHEMBL15485243 | 0.82 | LMNA (0.67) | CD274LMNACYP2C19ALDH1A1POLB | |
| SCHEMBL31504829 | 0.82 | CYP2C19 (0.58) | CD274LMNACYP2C19ALDH1A1HTR1A | |
| SCHEMBL3543817 | 0.81 | CD274 (0.92) | CD274CYP2C19ALDH1A1HTR1AMAOA | |
| SCHEMBL77220 | 0.81 | KMT2A (0.65) | LMNAALDH1A1KMT2A | |
| SCHEMBL8771374 | 0.80 | CYP2C19 (0.69) | CD274LMNACYP2C19ALDH1A1HTR1A | |
| SCHEMBL18845433 | 0.80 | CYP2C19 (0.78) | CD274CYP2C19ALDH1A1HTR1AMAOA | |
| SCHEMBL8722300 | 0.80 | MEN1 (0.60) | CD274ALDH1A1HTR1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034426-A | Reaction of polyisocyanate, polyol and a chain extender which is also a catalyst because of a tert-amine side chain | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4937306-A | For polyurethanes | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1990-06-26 | — | — | US | disclosed |