Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760318 | 0.90 | HSD17B10 (0.48) | TSHRL3MBTL1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4985915 | 0.88 | HSD17B10 (0.50) | TSHRL3MBTL1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL10561030 | 0.87 | POLB (0.55) | ALDH1A1SMN1; SMN2GAAPOLBLMNA | |
| SCHEMBL8892737 | 0.85 | POLB (0.55) | TSHRALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL22256279 | 0.83 | TSHR (0.55) | TSHRSMN1; SMN2GAAPOLBHSD17B10 | |
| SCHEMBL9760024 | 0.82 | HDAC8 (0.58) | L3MBTL1ALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL9761396 | 0.82 | HDAC8 (0.58) | L3MBTL1ALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL29260895 | 0.82 | TSHR (0.56) | TSHRSMN1; SMN2GAAPOLBHSD17B10 | |
| SCHEMBL9760700 | 0.81 | ALDH1A1 (0.47) | TSHRL3MBTL1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1989875 | 0.80 | ALDH1A1 (0.61) | L3MBTL1ALDH1A1POLBMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026863-A | Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4983740-A | Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide | ADIR ET COMPAGNIE (FR) | 1991-01-08 | — | — | US | disclosed |
| US-4870091-A | CALCIUM CHANNEL BLOCKERS | ADIR ET CIE (FR) | 1989-09-26 | — | — | US | disclosed |